SPINAL MUSCULAR ATROPHY
SPINAL MUSCULAR ATROPHY is a kind of motor neuron disease and falls under a genetically heterogeneous group of hereditary neurologic diseases. Motor neurons are nervous cells of the spinal cord that trigger muscle motion required for carrying out motor functions. This particular disease involves a gradual degeneration of motor neurons located in the anterior horns of the spinal cord, and in some cases in the motor nuclei of the brain stem. Patient experiences a mutation in the survival motor neuron gene responsible for producing a protein which is crucial for normal functioning of the motor neurons.
An absence of this protein leads to a condition where there is an atrophy of nerve cells, reduction in their sizes and eventual death resulting from muscle weakness.
Some clinical symptoms of SMA may be as follows:
- Paresis and atrophy of striated muscles
- Fasciculations
- Lesion of proximal muscles, bulbar syndrome, asymmetric muscle lesion
- Spine deflection
Mesenchymal Stem Cells (ucbMSCs) therapy has reported positive results in patients with this condition. There has been a marked remission of in 75% of patients and reduced neurogenic dystrophy in 92% cases.
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