Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis

Abstract: Osteoarthritis (OA) is a common disorder and the restoration of the diseased articular cartilage in patients with OA is still a challenge for researchers and clinicians. Currently, a variety of experimental strategies have investigated whether mesenchymal stem cells (MSCs) instead of chondrocytes can be used for the regeneration and maintenance of articular cartilage in OA. MSCs can modulate the …

Tissue Engineering with Mesenchymal Stem Cells

Transplant surgery is a leading therapy to treat organ failure or tissue loss. In 2001 in the United States alone, despite 24,076 lifesaving organ transplants, 6,439 people died waiting for a transplant, leaving 84,798 registrations on the waiting list for an organ at the end of the year [1]. It is clear that organ transplant alone is not a viable …

Mesenchymal stem cell

A category of adult stem cells is represented by mesenchymal stem cells. Mesenchymal stem cells are found in very large numbers in the bone marrow and Wharton’s Jelly region of the umbilical cord (Wharton’s Jelly or “Wharton jelly” is mucoid connective tissue that constitutes the extracellular matrix of the umbilical cord and includes blood vessels, protecting them).